Pulisic will support Goncalo Ramos in the attack, with versatile Alexis Saelemaekers also featuring in the starting XI. The move comes after Pulisic struggled with fitness issues, even during the USMNT's World Cup campaign. The 23-year-old American will be looking to make an impact in his first start of the season.
The pressure is already building on Amorim after a dismal run of results, including draws with Juventus and Lazio, as well as a 2-0 home defeat to Benfica in the Europa League. The coach was criticised for excessive squad rotation in Wednesday's game, so returns Luka Modric, Adrien Rabiot, and Mario Gila to the starting XI.
The match kicks off at San Siro at 19.45 UK time (20.45 CEST).