The Vasco da Gama coach, João Almirante, has been rotating his squad to manage the physical demands of competing in multiple competitions. The team is currently fighting to avoid relegation in the Brasileirão and is also chasing titles in the Copa do Brasil and Copa Sul-Americana. As a result, players with the most recent time of game will undergo physical tests hours before the match. If the results indicate that they are near a limit of wear, they will be rested.
The probable lineup for the match against Independiente Santa Fé is expected to feature a mix of regular starters and reserve players. The team will need to win by any score to secure a spot in the semi-finals, with a draw leading to a penalty shootout.