Inter's recent form in the Champions League has been inconsistent, with the team winning both the Serie A and Coppa Italia titles in 2025-26 but failing to give their best account of themselves in Europe after a knock-out play-off round elimination at the hands of Bodo/Glimt. The Nerazzurri had reached the final in two of the three preceding seasons, losing to Manchester City in 2022-23 and Paris Saint-Germain in 2024-25.

According to Opta predictions, Inter are ranked as the ninth-most likely side to win the Champions League in 2026-27. Premier League champions Arsenal are the pre-tournament favourites, followed by Bayern Munich, Manchester City, Barcelona and PSG to complete the top five. Opta has also predicted that Liverpool, Real Madrid and Manchester United have a greater chance of winning the 2026-27 Champions League compared to the Nerazzurri.

Inter's head coach, Cristian Chivu, will be looking to improve on the team's 2025-26 result, which saw them eliminated in the knock-out play-off round. The team's chances of reaching the final or improving on their previous season's result remain uncertain, with many factors still to be determined.