PSV's defense is expected to consist of Sergino Dest, Lutsharel Geertruida, Armando Obispo, and Filip Kostic, with Matej Kovar in goal. Kostic will replace Mauro Júnior, who is absent due to a suspension. The midfield is expected to remain unchanged from the 1-3 win against Ajax, with Noah Fernandez preferred over Paul Wanner.

Ruben van Bommel and Ivan Perisic will again be responsible for creating danger from the flanks, while Ricardo Pepi will lead the attack. The American has a good memory of a previous match against Shakhtar, having scored in PSV's 3-2 win in November 2024.