Napoli have made a significant change in the off-season, with Antonio Conte walking away and Allegri taking over. The new coach has made a few changes to the starting line-up, with Scott McTominay, Rasmus Hojlund, and Alisson Santos all making their debut for the club. Kevin De Bruyne, who has been eased into the campaign after his World Cup experience with Belgium, is benched, with Andre Frank Zambo Anguissa taking over in midfield.

The line-up for Napoli features a 4-3-3 formation, with Alisson Santos and Matteo Politano flanking Hojlund. Rafa Marin and Amir Rrahmani form the defence, with McTominay and Stanislav Lobotka in support. Genoa, on the other hand, have a lengthy list of problems to deal with, including injuries to Hamed Traore, Lorenzo Venturino, and Elias Havel. Despite all the transfer speculation, Brooke Norton-Cuffy remains part of the side and starts out wide.

Genoa's season already began with a 4-1 Coppa Italia victory over Ascoli last week, but they will be looking to build on that momentum against Napoli. The match kicks off at the Stadio Luigi Ferraris at 19.45 UK time (20.45 CEST).