The current champion, Inter de Milán, will look to defend its title against a competitive field that includes three new teams: Venezia, Frosinone, and Monza. The top six teams in the league will qualify for European competitions, with the top four earning a spot in the Champions League, the fifth-placed team competing in the Europa League, and the sixth-placed team entering the Conference League playoffs. The bottom three teams will be relegated to a lower division.
A total of 12 teams in the Serie A will feature Argentine players, while eight teams will not have any Argentine representation. Notably, there are no Argentine coaches in the league. Some of the notable Argentine players in the Serie A include Lautaro Martínez, the captain of Inter de Milán, and Franco Mastantuono, who has joined Fiorentina on loan from Real Madrid.
The first matchday of the season will see Inter de Milán take on Monza at 13:30 on Saturday, 22 August, while Udinese will face Como at the same time. The full schedule for the first matchday is as follows: Saturday, 22 August - 13:30: Inter vs. Monza, Udinese vs. Como; Sunday, 23 August - 13:30: Frosinone vs. Juventus, Venezia vs. Lecce; Monday, 24 August - 13:30: Bologna vs. Lazio, 15:45: Roma vs. Fiorentina.