The four players who suffered from injuries are Victor Sá, Newton, Aurélio Buta, and Domingos Duarte. Victor Sá, an attacker, suffered a sprained ankle during a training session in August and was out for 17 days. He missed three games for São Paulo and returned in a 1-0 loss to Boca Juniors in the Sul-Americana on September 9.
Newton, a midfielder, suffered an edema in his left thigh in late August and was out for a game. He also missed a match against Internacional due to a trauma in his right thigh. Aurélio Buta, a right-back, will be out for at least two months after undergoing surgery for a meniscus injury in his right knee. Domingos Duarte, a centre-back, suffered a ruptured anterior cruciate ligament in his right knee and will be out for the entire 2027 season.
The injuries have affected São Paulo's performance, with the team playing seven consecutive games with at least one of the contracted players out due to a physical problem. The team will have the Data Fifa period to recover some of the injured players before returning to action on October 2 against Santos.