Roma will be without Lorenzo Pellegrini, who is unavailable for the match, while Fiorentina have travelled to the capital without the injured Fabiano Parisi. Roma will stick to their usual 3-4-2-1 system, with Dybala playing as an attacking midfielder behind Donyell Malen. New signing Rodrigo Mora will challenge Matias Soulé for the other spot as an attacking midfielder.
Fiorentina, on the other hand, will look to a 4-3-2-1 system, with Franco Mastantuono expected to get the nod over Arthur Atta. Joao Mario appears favourite over Alex Jimenez at right-back, while the starting striker for the visitors will be either Kean or Pellegrino. According to Sky Sport, Kean will get the nod, but Gazzetta claims that Pellegrino is the favourite.
The match will be played at the Stadio Olimpico in Rome, with kick-off at 20:45 CET. Football Italia will provide live updates for the match via a live blog.