Pepi has been replaced by Damion Downs in the USMNT 28-man squad for the upcoming four friendlies against Peru, Chile, Mexico, and Canada in the September-October FIFA window. The injury is considered a "minor setback" by Pepi, who has already started his recovery to return to action with his club.
Pepi lasted only eight minutes in PSV's match against FC Twente on Sunday before raising his hand to the bench and sinking to the turf. Mauricio Pochettino's side is now missing its three key forwards from the World Cup - Folarin Balogun, Christian Pulisic, and Pepi.
PSV Eindhoven's next match is on October 9 against Heerenveen at home, with away matches against RB Leipzig, ADO Den Haag, and FC Porto on the schedule.