Inter Miami, currently third in the Eastern Conference with 46 points from 26 matches, will face Columbus Crew, who are 13th in the same conference with 26 points. The match is set to take place on Sunday, 27 September. Kily González's side will be without key players Lionel Messi and Rodrigo De Paul, who have been called up to their respective national teams. This will be González's second match in charge of Inter Miami, following their 2-2 draw against San Diego. The team will have to adapt to the absence of these players, as they look to maintain their position in the title race.