The injuries have piled up for top clubs, with Sunderland set to be without Brian Brobbey, a key striker, and Dan Ballard, a defensive mainstay, due to strains picked up playing for the Netherlands and Northern Ireland respectively. Bournemouth, yet to win a Premier League match, have lost Alex Scott for up to two months. His performance for England in their 7-0 victory against Croatia won rave reviews, but came at a heavy cost.

Arsenal still had 17 players called up for internationals, but Mikel Arteta is counting them back into training with concern. Ezri Konsa's withdrawal from the England squad on Monday followed injuries for Christos Tzolis and Kai Havertz. Playing for Greece against the Netherlands, Tzolis pulled his shirt over his head after injuring a hamstring. Against the same opponents, playing for Germany, Havertz suffered a similar problem.

The injuries are not confined to English football, with elite European players also affected. Bayern Munich have lost Jamal Musiala to the torn muscle in his right thigh sustained on international duty with Germany. The Premier League weekend's other headline clash, Manchester United hosting Tottenham in a derby of fading dreams, will also be without key personnel. United's Patrick Dorgu pulled up with a hamstring injury when playing for Denmark.

The injuries have left clubs scrambling to adjust their lineups, with some players set to miss crucial matches. The next step for these clubs will be to assess the severity of the injuries and plan for the upcoming matches.